ImpriMed's list

drugs that may be poorly tolerated by dogs with MDR1 mutation

Data SourceS:

Martinez M, Modric S, Sharkey M, Troutman L, Walker L, Mealey K. The pharmacogenomics of P-glycoprotein and its role in veterinary medicine. J Vet Pharmacol Ther. 2008;31(4):285-300. doi:10.1111/j.1365-2885.2008.00964.x
Mealey KL, Fidel J. P-glycoprotein mediated drug interactions in animals and humans with cancer. J Vet Intern Med. 2015 Jan;29(1):1-6. doi: 10.1111/jvim.12525. PMID: 25619511; PMCID: PMC4858061.
Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):313-33, vii. doi: 10.1016/j.cvsm.2011.12.005. PMID: 22381182; PMCID: PMC4152460.

Anticancer

Actinomycin D, Docetaxel, Doxorubicin, Etoposide, Mitoxantrone, Vinblastine, Vincristine

Antimicrobial

Doxycycline, Erythromycin, Itraconazole, Ketoconazole, Levofloxacin, Sparfloxacin, Tetracycline

Antifungal

Itraconazole, Ketoconazole

Antidepressants

Amitriptyline, Paroxetine, Venlafaxine

Steroid Hormones

Aldosterone, Cortisol, Dexamethasone, Hydrocortisone, Methylprednisolone, Triamcinolone

Opioids

Butorphanol, Loperamide, Methadone, Morphine, Pentazocine